The French Daily All-Media Reporter Lian Yingting Correspondent Shao Longfei Zhang Zhenwei The night in Wuhan is quiet.
On March 9, in the mobile testing laboratory of the Central Theater Command General Hospital, Jiang Tao, a researcher at the Military Medicine Research Institute of the Academy of Military Sciences, reviewed the last sample test data and solemnly signed his name on the test report.
At this time, it was already 5 a.m.
Babaylan He is an expert in virology and a warrior who aided Africa in the war against Egypt. This time, the new crown epidemic broke out, and he was once again ordered to go to the front line after a long battle.
Human life is at stake
Nucleic acid testing is crucial for early clinical detection, early diagnosis, early isolation, and early treatment. It is a key technical support for effective prevention and control of the new coronary pneumonia epidemic.
”The cold-looking sample tube is behind the patient’s fresh life and health. If a diagnosis is released early, the accurate inspection will be conducted sooner.” Jiang Tao said. On January 26, after a military medical expert group led by Chen Wei, an academician of the Chinese Academy of Engineering and a researcher at the Military Medicine Research Institute of the Academy of Military Sciences, arrived in Wuhan, Hubei Province, he quickly established a joint defense, joint control, joint treatment and joint research mechanism with relevant military and local units around the new coronavirus’s pathogen transmission mutation, rapid detection technology, vaccine antibody development, etc.
According to the division of tasks, Jiang Tao led the testing team to build a nucleic acid testing platform in the experimental cabin overnight.
Focusing on three aspects: ensuring biosafety, improving detection efficiency and detection accuracy, Jiang Tao took the lead in formulating biosafety operation specifications and emergency plans, reasonably divided testing and division of labor according to the characteristics of the team members, and using self-developed testing test kits to use fully automatic Komiks high-throughput extractors, laying the foundation for achieving fast and efficient testing.
Receiving samples, sorting numbers, nucleic acid extraction, reagent preparation, machine amplification, and result interpretation, the nucleic acid detection machinery is boring and full of risks.
The biggest riskIt is an invisible virus. If the nucleic acid Cinema is not completely cleaved or inactivated thoroughly enough, it is possible to expose the detector to danger.
Jiang Tao always takes the initiative to participate in the longest and most risky nucleic acid extraction. After the sample is extracted, he will arrange some people to rest and stick to the experimental room and wait for the final result.
The full-process Cinema nucleic acid test is relatively fixed from the number of tests in a single batch to the preparation for entry and exit of personnel and the inspection time. Sometimes there are a large number of samples sent for inspection. The inspectors not only take turns to work, but also have to work overnight. The final confirmation result must be at four or five o’clock in the morning. Li Hao, a researcher at the testing team, said that this situation will be encountered once every few days.
”Everyone should open their eyes wide. Be sure to take good protection when receiving and processing samples, and pay attention to whether there are sharp objects.” Before each test begins, Jiang Tao always reminds you repeatedly.
In the detection Komiks, the strength of the fluorescence signal of the pathogenic gene directly affects the determination of the detection results. If there are suspicious phenomena such as the detected fluorescence curve signal is low or there is only a single target, Jiang Tao will convene personnel to conduct comprehensive analysis and judgment, and if necessary, repeat the test for review to ensure that the results can stand the test.
”A false positive will cause healthy people and patients to be isolated and infected; a false negative will cause real patients to be delayed in treatment. Life is a matter of life, and no gap will be allowed.” Jiang Tao said.
All-rounded people in the field of epidemic prevention and control
According to prevention and control requirements, the nucleic acid test results must be completed within 24 hours after receiving the pharyngeal swab sample. In order to let the hospital know the results as soon as possible to treat patients, Jiang Tao led the team to optimize the process combination and compressed the time to within 4 hours, achieving the ability to extract nucleic acids of more than 90 samples within one hour and a single-day sample detection capability of up to more than 500 people.
”The team’s inspection is efficient and fast, the results are accurate and extremely slowRelieve the pressure on our epidemic prevention and control sample detection. “Wuhan Center for Disease Control and Prevention highly praised this.
The rapid response during wartime and the orderly work is carried out, all thanks to Jiang Tao’s practical academic foundation and rich practical experience.
”Jiang Tao is a versatile. “Academician Chen Wei, head of the military medical expert group, commented.
Jiang Tao has successively presided over and participated in the separation of pathogenic etiology such as SARS infection cases, H7N9 infection cases, Zika infection cases, etc., participated in the development of dengue fever vaccines and SARS vaccines, and established a pathogen isolation technology platform, nucleic acid detection technology platform and pathogenicity and transmission risk assessment platform for a series of infectious diseases, providing important technical support for the prevention and control of infectious diseases.
Respiratory infectious diseases are characterized by rapid transmission, wide coverage, and great harm. Effective early diagnosis and prevention are crucial. After many years href=”https://comicmov.com/”>Komiks scientific research, Jiang Tao’s team took the lead in establishing our army’s first acute respiratory infectious disease monitoring and early warning system, and built a four-level monitoring system for the entire army. The series of technical specifications he presided over were used throughout the army, greatly reducing the detection and screening time of respiratory epidemics.
Jiang Tao not only participated in the security tasks of a series of major domestic activities, but also went to Africa four times to Liberia, Sierra Leone and other countries to carry out medical assistance tasks.
In 2015, in order to prevent and control the Ebola epidemic, Jiang Tao went to Sierra Leone for the second time with the testing team of the mobile laboratory to assist in Sierra Leone. The testing team led by him passed the World Health Organization with full scoresCinema‘s parallel laboratory capability assessment.
In 2018, Jiang Tao led the pathogen monitoring team to participate in a special simulation test by an international organizationBabaylan. In the virus test moduleCinema, the team<a The team successfully detected monkeypox virus, vaccinia virus and other pathogens in the simulated samples filled with impurities, and accurately determined the strain, achieving excellent results with full marks.
Improving the accuracy of clinical diagnosis
When I came to Wuhan, except for the openingIn addition to conducting testing, Jiang Tao also used his professional expertise in the research field to lead the testing team to screen other common respiratory infectious diseases in clinical samples.
”In the suspected and confirmed cases of new coronavirus pneumonia, whether there are other respiratory virus infections or co-infections, this is of great reference value for precise prevention and control and clinical treatment.” Researcher Cao Wuchun, deputy head of the Military Medical Expert Group, said.
Exploring deep-seated virus transmission and pathogenic mechanisms is the key to defeating the epidemic. Regarding the novel coronavirus detected in clinical samples, Jiang Tao led a team to continue to conduct sequencing analysis.
As the development of the diseaseKomiks‘s poison epidemic, whether the genomic sequences have mutated and what are the characteristics of the mutations; in which regions and what are the effects, Jiang Tao and his team are tirelessly studying and exploring.
In order to accelerate the effective integration of scientific research and clinical practice, Jiang Tao’s military medical expert group creatively used the diagnostic chain of viral nucleic acid detection, antibody detection, multiple pathogen detection, and whole genome sequencing to accurately diagnose the original infection of new coronavirus or other diseases in clinical patients, and was also used in the Optical Valley Campus of Hubei Maternal and Child Health Hospital, and in Wuhan Taikang Tongji Hospital and other hospitals, effectively improving the accuracy of clinical diagnosis.
Forgot his family when he was ordered. After the epidemic is over, Jiang Tao plans to accompany his family. He and his wife agreed that when the epidemic is over, they will take their wife and children to Wuhan again to see how everything will look after it is normal, and to see the Wuhan Yangtze River Bridge and Huanghe Tower, and to talk about their experience in fighting the epidemic in Wuhan.
The epidemic is immortal and the charge continues. This is Jiang Tao, a warrior who fights the epidemic.